1964 Kiel Chloroquine Suicide Sudden death due to chloroquine overdosage is uncommon. Thirteen fatal cases, involving 12 persons stationed in the Far East and one arthritic patient in this country, have been submitted to the Forensic Pathology Branch, indicating a new problem in the field of suicide. 1981 Das Chloroquine-related depression. Drugs are known to induce depressive states. Chloroquine, an antimalarial, in therapeutic doses administered for malaria therapy, may produce symptoms rather indistinguishable from endogenous depression. The possible mechanisms of production of depression related to chloroquine use are hypothesised. 1981 Mohan-Das CHLOROQUINE—RELATED DEPRESSION Drugs are known to induce depressive states. Chloroquine, an antimalarial, in therapeutic doses administered for malaria therapy, may produce symptoms rather indistinguishable from endogenous depression. The possible mechanisms of production of depression related to chloroquine use are hypothesised. 2002 Guardian 'It's not a benign drug - it has ruined my life' Thousands take the anti-malarial drug Lariam every year, most without any problems. But some claim it causes serious side effects, ranging from depression to suicidal - or even homicidal - impulses. So should it be banned? Mark Honigsbaum investigates

2004 Meier The risk of severe depression, psychosis or panic attacks with prophylactic antimalarials. Experimental and observational studies have linked mefloquine use to an increased risk of developing neuropsychiatric adverse effects such as depression or psychoses. Most of these reports relied on interview-based information from travellers. We conducted a population-based observational study using a database of medical records to quantify and compare the risk of psychiatric disorders during or after use of mefloquine with the risk during use of proguanil and/or chloroquine, or doxycycline. 2013 Hangartner Chloroquine and diazepam for her last sleep 2016 Telegraph Antimalaria pills linked to depression: what travellers need to know If you are planning to visit any place where there is a malaria risk – including parts of Latin America, sub-Saharan Africa and Asia – chances are you’ll be advised to take preventative medication. But with this week’s news that Lariam – one of the main antimalarial treatments on the market – has been linked to widespread anxiety and depression among British troops, should you be worried about the side effects too?