rs79.vrx.palo-alto.ca.us
References

Electron micrograph of MARV, the Marburg virus and Se distribution in Africa.


"Filoviruses are among the most pathogenic of human viruses. They are classified as “Biological Level 4” agents (WHO; Risk Group 4) based on their high mortality rate, person-to-person transmission, potential aerosol infectivity, and absence of vaccines and chemotherapy.

Filoviruses — like all RNA viruses — presumably have a potential for rapid evolution because of an inherently high error rate of the virus encoded polymerase and a lack of repair mechanisms. The consequence may be a spectrum of genetic variants that are selected by the host for different transmissibility, virulence, and other biological properties."

Marburg and Ebola Viruses Heinz Feldmann, Hans-Dieter Klenk
http://www.sciencedirect.com/science/article/pii/S0065352708607332

Because the disease can only affect animals that have to little ascorbate, nearly always those that do not make their own ascorbate, then in one sense it's like a global antibody the culls out defective genetics in animal species. It turns the human body to soup by eating the connective tissue that holds the body together so it can extract the ascorbate out of it to use to make new copies of itself.

bas_congo
Bas Congo Viral Disease

Rabies + Ebola is the best way to describe this newly discovered virus. Oddly, although it kills some people very quickly, and in as little as three says, other poeple survive it, In fact, checking the blood of the poeple in Congo, it was gounf abuot half of them have had repeated exposure to the virus and never fell ill. Thsi is similar to the "myterious case of Ebola immunity" and almost certainly has the same cause.


First micrograph of the Marburg virus
 Plasma membrane lipids and parainfluenza virus assembly  Susceptibility to superinfection of simian cells transformed by SV40  Whole genome molecular phylogeny of large dsDNA viruses using composition vector method
 Structure Unifies the Viral Universe  Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond  Virulence genes of Rickettsia rickettsii are differentially modulated by   upshift or blood-feeding in tick midgut and salivary glands  Molecular aspects of MERS-CoV  Spatiotemporal Fluctuations and Triggers of Ebola Virus Spillover  Serologic Cross-Reactivity of Human IgM and IgG
 Coronavirus replication

Genetics, evolution and ecology of the Ebola virus

Also included are other highly pathogenic viruses.


care

What does a hospital do for Ebola

It varies. In Africa it has up to a 90% lethality rate. In the US and UK no infected citizen died on home soil. While it's only a handful of people, it's still a 0% mortality rate or 100% survivable which ever way you look at it.




genetics
 Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

Genetics and evolution of the Ebola virus.


hosts
 Pigs make their own ascorbate. Usually.But they don't when they're sick and can then catch Ebola. Also pathogenicity of the swine herpes virus may have come about the same was as in Ebola.

Animals that can catch Ebola

The short answer is any animal with scurvy is susceptible. Animals that make their own ascotbate are generally not susceptible to the virus but it can be induced if serum ascorbate is low.


lassa
Lassa fever, Marburg and Ebola virus diseases and other exotic diseases: is there a risk to Canada?

WS & Rudolf Siegert
 Forty Years of Marburg Virus
 Marburg Hemorrhagic Fever — The Forgotten Cousin Strikes

Discovery of the Marburg virus

Marburg is only half as lethal as Ebola and was discovered in 1967 in Marburg Germany at a lab that made polio vaccine from wild monkey kidneys. One was infected with Marburg and workers began dying and infecting other people. A new type of virus proved to be responsible and a new family was created for these, the Filovirus family. Less than a decade later the next member of the family would be discovered when a breakout of Ebola occurred simultaneously in Sudan and Zaire.


Selenium electrons
 Boosting serum Selenium   History and examples of selenium use in fighting  disease.
 The role of immune boosting agents on historical warfare.  Direct evidence Selenium mitiates Ebola  Keshen Disease and the analogous role of Selenium

Implications of selenium

The US Food and Nutrition Board lowered the RDA for selenium in the year 2000 from 70 mcg for men and 55 mcg/day for women to 55 mcg/day for both.

Evidence now suggets 100 mcg is the level at which Seactivity begins. Also most people do not even achieve the RDA level in the first place. One brazil nut a day supplies more than enough for a healthy person, 2 should be enough for a sick person akthough it should be noted for years poeple have eaten more than 2 Brazil nuts a day and managed to survive.


sympatric
 Genomic Characterisation of Vinegar Hill Virus, An Australian Nairovirus Isolated in 1983 from Argas Robertsi Ticks Collected from Cattle Egrets

Ecology of highly pathogenic viruses

Organisms living totally in isolation lacking evolutionary and competitive pressures tend not to evolve. Thus interaction with similar and unrelated species drives diversity. In the regions where pathogenic Ebola is found other common pathogens are worth enumerating due to potential interactions.


tellurium

More toxic and more potent then Selenium

It was only in 1957 that the importance of selenium to the immune system was discovered, prior to that it was regarded as a toxic pollutant. Tellurium suffers the same fate. Now however, evidence is beginning to trickle in that tellurium, by virtue of being the same row of the periodic table as Oxygen, Sulphur and Selenium has similar properties to Selenium but is more active. Caution needs to be exercised still as Tellurium is also more toxic than selenium. But as a future direction tellurium may have promise in future medicine - they did have a place in ancient medicine. Recall that "Head and Shoulders" shampoo uses selenium to kill bacteria and similarly so, "tellurite" has been used in the past as a bactericide.


timeline

The 2014 Outbreak Timeline - Chronology of the EBV Outbreak.

"On March 23, 2014, the World Health Organization (WHO) was notified of an outbreak of Ebola virus disease (EVD) in Guinea. On August 8, the WHO declared the epidemic to be a “public health emergency of international concern.”

"These data indicate that without drastic improvements in control measures, the numbers of cases of and deaths from EVD are expected to continue increasing from hundreds to thousands per week in the coming months."

These are the most significant events:

"We've now seen several cases that don't have any symptoms at all, asymptomatic cases," said Anavaj Sakuntabhai who suggested the virus might be mutating.
29 January 2015 Last updated at 00:55
http://www.bbc.com/news/health-31019097

Ebola Not Mutating, Scientists Say
Wednesday, May 13, 2015
http://www.nlm.nih.gov/medlineplus/news/fullstory_152522.html

British nurse cured of Ebola credits new drug - and strawberries
"Back in Britain, the decision to try MIL 77 was not difficult. “I said ‘I have Ebola, so, yes, I’d rather have that than high-dose vitamin C,’” she said"
“I reckon I’ve had 10 punnets,” joked Corporal Anna Cross, who smiled nervously as she talked for the first time after her treatment at the Royal Free Hospital in north London." (10 punnets would be about equal to two 1000mg injections a day)
http://www.telegraph.co.uk/news/worldnews/ebola/11499584/Nurse-who-became-first-in-world-to-be-cured-of-Ebola-by-experimental-drug-is-discharged.html

Semen found infected after 175 days, twice the previous record.
April 2015
http://io9.com/ebola-survivors-are-being-urged-to-abstain-from-sex-1698996342

Did real-time epidemic modeling save lives in West Africa?
28 May 2015 |
http://spectrum.ieee.org/computing/software/how-computer-modelers-took-on-the-ebola-outbreak





lassa: Lassa fever, Marburg and Ebola virus diseases and other exotic diseases: is there a risk to Canada?
https://europepmc.org/article/pmc/pmc1818857