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Canadian researchers investigating vitamin C as sepsis/flu/covid treatment
TORONTO -- On New Year’s Day, a 24-year-old woman from Manitoba fell sick with the flu. Five days later, Joanne Ens died of sepsis -- a condition that new analysis suggests is involved in one-in-five deaths worldwide.
Sepsis is a life-threatening immune response that occurs when the body’s reaction to infection begins to damage its own tissue. Sepsis has been linked to a variety of health problems, including lung infections, urinary tract infections and is most common in bacterial infections.
In Canada, an estimated 30,000 deaths per year have been linked to sepsis.
New analysis published Thursday in The Lancet suggests sepsis is implicated in 20 per cent of deaths worldwide and is twice as prevalent as previously believed. In 2017, 11 million people worldwide died in connection with sepsis.
But a team of Canadian doctors is trying to change those odds and improve survival by investigating the potential of Vitamin C infusions to protect the body from sepsis. The theory is that vitamin C could help protect organs and blood vessels that become vulnerable following the onset of sepsis.
“I feel excited and enthused by the prospect that this could be potentially life-saving therapy,” said Dr. Lamontagne. “If it is beneficial, it’s less expensive than a lot of the other treatments we administer.”
Dr. Tex Kissoon, a pediatric professor at the University of British Columbia, was a co-author in the new analysis published in The Lancet. He said the discovery that sepsis rates were twice what researchers previously believed represents a “seismic shift.”
“We were very surprised by this,” Kissoon told CTVNews.ca in a phone interview on Wednesday. “We did modelling over a period of years and we came to the conclusion that sepsis is indeed more common than we thought.”
Sepsis overwhelmingly affects children, with 40 per cent of cases occurring in kids younger than five. Eighty-five per cent of cases were reported in low- and middle-income countries in places such as sub-Saharan Africa, the South Pacific and Southeast Asia.
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Local hospital using experimental IV-C drug treatment saving lives of COVID-19 patients
One top doctor at at United Memorial Medical Center said a cocktail of drugs used in the past to treat major infections is proving 100% success with his COVID-19 patients
That treatment is a combination of cortizone[SIC], large doses of vitamin C and a blood thinner. Dr. Joseph Varon says it shows great promises for treating COVID-19.
“To date, we have 0% mortality at United Memorial Medical Center. Zero percent. I know it’s too good for people to believe in this but it’s working," Dr. Varon said.
Dr. Varon said the national Coronavirus Task Force, under the command of Vice President Mike Pence, has contacted him and currently examining his data.
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Doctor In Oregon, near death with coronavirus, saved with IV C
"Soon after being admitted to his own hospital with a fever, cough and difficulty breathing, he was placed on a ventilator. Five days after that, his lungs and kidneys were failing, his heart was in trouble, and doctors figured he had a day or so to live."
"Dr. Matt Hartman, a cardiologist, said that after four days on the immunosuppressive drug, supplemented by high-dose vitamin C and other therapies, the level of oxygen in Padgett’s blood improved dramatically. On March 23, doctors were able to take him off life support."
"Four days later, they removed his breathing tube. He slowly came out of his sedated coma, at first imagining that he was in the top floor of the Space Needle converted to a COVID ward."
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The University of Wisconsin in Madison has included intravenous Vitamin C as part of its treatment guideline.
The University of Wisconsin in Madison has included intravenous Vitamin C as part of its treatment guideline. It’s part of a combination therapy protocol developed in 2017 by Dr. Paul E. Marik at the Eastern Virginia Medical School in Norfolk.
If you can administer Vitamin C intravenously starting in the Emergency Room and every 6 hours thereafter, while in the hospital, the mortality rate of this disease and the need for mechanical ventilators will likely be greatly reduced,” says Dr. Pierre Kory, the Medical Director of the Trauma and Life Support Center and Chief of the Critical Care Service at the University of Wisconsin in Madison. He explains that it’s the inflammation sparked by the Coronavirus, not the virus itself, that kills patients. Inflammation causes a condition called Acute Respiratory Distress Syndrome (ARDS), which damages the lungs so that patients, suffering fever, fatigue, and the sense that their inner chest is on fire, eventually cannot breathe without the help of a ventilator.
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COVID-19 Marik Management Protocol
Developed and updated by Paul Marik, MD
Chief of Pulmonary and Critical Care Medicine
Eastern Virginia Medical School, Norfolk, VA
April 20th, 2020
URGENT! Please circulate as widely as possible. It is crucial that every pulmonologist, every critical care doctor
and nurse, every hospital administrator, every public health official receive this information immediately.
This is our recommended approach to COVID-19 based on the best (and most recent) literature. We
should not re-invent the wheel but learn from the experience of others. This is a very dynamic situation;
therefore, we will be updating the guideline as new information emerges. Please check on the EVMS
website for updated versions of this protocol.
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High Dose Intravenous Ascorbic Acid (Vitamin C) - A Treatment Strategy Directed at Suppressing
Hyper-Inflammation to Reduce the Need for Ventilators & Save Lives
NEW YORK, NY: Leading critical care specialists at five
academic or major hospitals who together have formed
the Front Line COVID-19 Critical Care Working
Group, have released MATH+ —a protocol for treating
patients who arrive in hospitals with COVID-19.
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Dr. Joseph Varon has worked 270 consecutive days and counting. He and his team use the MATH+ protocol, and see >95% of their Covid-19 patients survive.
Dr. Joseph Varon's team at United Memorial Medical Center in Houston, TX treated 140 hospitalized Covid-19 patients through July with a survival rate of 95.6%, and Dr. Paul Marik's team at Sentara Norfolk General Hospital in Norfolk, VA treated 191 hospitalized Covid-19 patients with a survival rate of 93.9%. A difference between the sites is that UMMC begins the protocol in the Emergency Department whereas Norfolk General begins the protocol in the ICU. In comparison, 461 other hospitals in the USA, UK, and China not using the MATH+ protocol had published survival rates ranging from 68% to 84.4%
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COVID patient with sepsis makes 'remarkable' recovery following megadose of vitamin C
Dec. 2, 2020
A young Australian man who was critically ill with COVID-19 and suffering early stages of sepsis made a remarkable recovery after being given massive doses of vitamin C, according to his doctors.
Professor Rinaldo Bellomo, director of Intensive Care at Melbourne's Austin Health, said the 40-year-old's health had started to deteriorate significantly from COVID-19, with the man losing kidney function, and his blood pressure plummeting.
Sepsis — a life-threatening condition which occurs when the body damages its own organs while responding to an infection — was starting to take hold of his body and time was running out.
"We were dealing with somebody who was very unwell. We felt we were in a very difficult situation, and the patient's life was under serious threat," he said.
Professor Bellomo knew researchers at the Florey Institute had some promising experimental findings using megadose vitamin C to treat sepsis.
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New York hospitals are treating coronavirus patients with high dosages of Vitamin C after promising results from China
Dr Andrew Weber says he has been immediately giving his intensive-care patients 1,500 milligrams of intravenous vitamin C
The Long Island-based pulmonologist and critical-care specialist with Northwell Health says patients are given three to four doses a day
The regimen is based on experimental treatments that were done in China
Jason Molinet, a spokesman for Northwell, says Vitamin C is being 'widely used' as a coronavirus treatment throughout the health system
A clinical trial into the effectiveness of intravenous vitamin C patients with coronavirus was conducted on February 14 at Zhongnan Hospital in Wuhan
The patients who received vitamin C did significantly better than those who did not get vitamin C,' he said. 'It helps a tremendous amount, but it is not highlighted because it's not a sexy drug.'
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"All patients who received intravenous vitamin C improved, and there was not one mortality"
Dr. Mao has been using large doses of IVC to treat patients with acute pancreatitis, sepsis, surgical wound healing, and other medical conditions for over 10 years. This time around when Covid-19 broke out, he and other experts thought of IVC and recommended IVC for the treatment of moderate to severe cases of Covid-19 patients. The recommendation was accepted by the Shanghai Expert Team early on. All Covid-19 patients in the Shanghai area have been treated in Shanghai Public Health Center, there has been a total of 358 Covid-19 patients as of March 17th, 2020.
Dr. Mao stated that his group treated ~50 cases of moderate to severe cases of Covid-19 infection with high dose IVC. The IVC dosing was around 10,000 mg – 20,000 mg a day for 7-10 days, with 10,000 mg for moderate cases and 20,000 for more severe cases by the pulmonary status (mostly the oxygenation index) and the coagulation status.
All patients who received IVC improved and there was no mortality. Compared to the average of 30-day hospital stay for all Covid-19 patients, those patients who received high dose IVC had a hospital stay that‘s about 3-5 days shorter than the overall patients.
Dr. Mao discussed one severe case in particular who was deteriorating rapidly. He gave a bolus of 50,000 mg Vit C IV over a period of 4 hours. They watched the patient’s pulmonary (oxygenation index) status stabilizing and improving in real-time. There were no side effects reported to all the cases treated with high dose IVC.
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IV-C worked instead of ventilator when chloroquines failed
This is a really good sign. In China they used IV C. Marik's protocol is C + B1 + cortisone. These guys used C + Mg + K which is not documented anywhere. This means they looked at the blood, noted deficiency and added the appropriate nutrients. Linus Pauling would be so proud. Hospitals are finally using orthomolecular principles - and of course, with success. Had she been placed in a ventialtier instead then she would have had only a 1 in 5 chance of survival.
"STATEN ISLAND — Christina Paz, a mother of five, was very close to needing a ventilator in the critical care unit at Staten Island University Hospital. The experimental, anti-malaria medication doctors gave her to stop the invasion of COVID-19 inside her body wasn’t working. The physicians then started giving her high doses of Vitamin C with an IV antibiotic, coupled with magnesium and potassium."
"Paz, a realtor, first got sick in the middle of March and thought she had a cold. She had a low grade fever and thought she was simply run down. “Within a day, it turned into something I knew wasn’t a regular cold,” Paz said. Her husband, Enrique, took Paz to the hospital March 21 and she wasn’t getting better. Christina Paz was discharged from the hospital after 15 days, Paz said her post-hospital recovery could take four to six weeks. She had no underlying conditions before contracting COVID19."
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when the World Health Organization (WHO) included vitamin C in its list of COVID-19 research priorities, Toronto's Sunnybrook hospital LOVIT trial aims to find out if intravenous vitamin C help critically ill COVID-19 patients.
But when the World Health Organization (WHO) included vitamin C in its list of COVID-19 research priorities, Dr. Adhikari knew they could contribute to that research effort by making some minor modifications to the LOVIT trial.
The LOVIT trial, which is examining whether high-dose intravenous vitamin C can lessen organ dysfunction in septic intensive care unit (ICU) patients, first began recruiting patients at 25 Canadian ICUs a year and a half ago, long before the emergence of COVID-19.
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Could vitamin C help cure COVID-19? A Canadian trial hopes to find out
The trial run by physicians in Montreal and Toronto was originally set up to treat patients suffering any kind of infection that landed them in the ICU with sepsis, an out-of-balance immune response to contagions that can damage multiple organs.
But it was modified late in March to also specifically include patients with COVID-19. Since then, the study has enrolled more than 25 pandemic patients with sepsis, says Dr. Neill Adhikari of Toronto’s Sunnbyrook Health Sciences Centre, one of the study’s lead investigators. He hopes to increase that number to as many as 800, possibly by linking up with a different, international coronavirus trial.
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