rs79.vrx.palo-alto.ca.us

2007 Wen

2020 Kiran

artemisia

2007 Wen Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus In this study, 221 phytocompounds were evaluated for activity against anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) activities using a cell-based assay measuring SARS-CoV-induced cytopathogenic effect on Vero E6 cells. Ten diterpenoids (1-10), two sesquiterpenoids (11 and 12), two triterpenoids (13 and 14), five lignoids (15-19), curcumin (20), and reference controls niclosamide (21) and valinomycin (22) were potent inhibitors at concentrations between 3.3 and 10 µM. The concentrations of the 22 compounds to inhibit 50% of Vero E6 cell proliferation (CC50) and viral replication (EC50) were measured. The selective index values (SI ) CC50/EC50) of the most potent compounds 1, 5, 6, 8, 14, and 16 were 58, >510, 111, 193, 180, and >667, respectively. Betulinic acid (13) and savinin (16) were competitive inhibitors of SARS-CoV 3CL protease with Ki values ) 8.2 ( 0.7 and 9.1 ( 2.4 µM, respectively. Our findings suggest that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects. 2020 Kiran In Silico Computational Screening of Kabasura Kudineer - Official Siddha Formulation and JACOM against SARS-CoV-2 Spike protein Spike protein is an important target for binding with the ACE2 of the host cell, and the inhibitors of this protein could be a potential target for COVID-19 infection. In this study, we have done the In silico molecular docking studies for the 37 Phytoconstituents against the spike protein of SARS-COV-2 (PDB ID: 6VSB). The results shown that Chrysoeriol and Luteolin from Kabasura Kudineer Chooranam and Quercetin from JACOM have high binding affinity and good binding interactions with spike protein. Further, In silico Pharmacokinetic and Toxicity prediction shown that all the Phytoconstituents have good oral bioavailability and free from toxicity. Based on these, we proposed the new formulation called as “SNACK–V” which contains nine Phytoconstituents from the six plant herbs.

artemisia 2015 Kim Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.