Can a genetically-modified organism-containing diet influence embryo development? A preliminary study on pre-implantation mouse embryos.
"In eukaryotic cells, pre-mRNAs undergo several transformation steps to generate mature mRNAs. Recent studies have demonstrated that a diet containing a genetically modified (GM) soybean can induce modifications of nuclear constituents involved in RNA processing in some tissues of young, adult and old mice. On this basis, we have investigated the ultrastructural and immunocytochemical features of pre-implantation embryos from mice fed either GM or non- GM soybean in order to verify whether the parental diet can affect the morpho-functional development of the embryonic ribonucleoprotein structural constituents involved in pre-mRNA pathways. Morphological observations revealed that the general aspect of embryo nuclear components is similar in the two experimental groups. However, immunocytochemical and in situ hybridization results suggest a temporary decrease of pre-mRNA transcription and splicing in 2-cell embryos and a resumption in 4-8-cell embryos from mice fed GM soybean; moreover, pre-mRNA maturation seems to be less efficient in both 2-cell and 4-8-cell embryos from GM-fed mice than in controls. Although our results are still preliminary and limited to the pre-implantation phases, the results of this study encourage deepening on the effects of food components and/or contaminants on embryo development."
Published in the International Journal of Environmental Research and Public Health and titled, "Non-Hodgkin Lymphoma and Occupational Exposure to Agricultural Pesticide Chemical Groups and Active Ingredients: A Systematic Review and Meta-Analysis," the paper focused on systematic reviews and a series of meta-analysis of almost 30 years worth of epidemiological research on the relationship between non-Hodgkin lymphoma (NHL) and occupational exposure to 80 agricultural pesticide active ingredients and 21 chemical groups. The review focused on 44 papers, all of which reported results from studies performed in high-income countries.
The study opened with mention of the "striking increase" observed in the incidence of non-Hodykin's type lymphomas in the last 30 years. Because farmers tend to have low overall mortality but high rates of some cancers, it is believed that agrochemical exposure may help to explain this contradiction.