Doubts about Johns Hopkins research have gone unanswered, scientist says
"The numbers didn’t add up.
Over and over, Daniel Yuan, a medical doctor and statistician, couldn’t understand the results coming out of the lab, a prestigious facility at Johns Hopkins Medical School funded by millions from the National Institutes of Health.
He raised questions with the lab’s director. He reran the calculations on his own. He looked askance at the articles arising from the research, which were published in distinguished journals. He told his colleagues: This doesn’t make sense.
“At first, it was like, ‘Okay — but I don’t really see it,’ ” Yuan recalled. “Then it started to smell bad.”
John Arnold Made a Fortune at Enron. Now He’s Declared War on Bad Science
"John Ioannidis was put in touch with the Arnolds in 2013. A childhood math prodigy turned medical researcher, Ioannidis became a kind of godfather to the science reform crowd in 2005, when he published two devastating papers—one of them titled simply “Why Most Published Research Findings Are False.” Now, with a $6 million initial grant from the Arnold Foundation, Ioannidis and his colleague Steven Goodman are setting out to turn the study of scientific practice—known as meta-research—into a full-fledged field in its own right, with a new research center at Stanford.
British doctor Ben Goldacre also got an email from the Arnold Foundation in 2013. Famous in England as a sharp-witted scourge of “bad science,” Goldacre spent years building up a case that pharmaceutical companies, by refusing to reveal all their data, have essentially deceived the public into paying for worthless therapies. Now, with multiple grants from the Arnolds, he is leading an effort to build an open, searchable database that will link all publicly available information on every clinical trial in the world."
Remember that scene early in Fight Club, when Edward Norton explained his job, when it was more profitable to let a car defect go and pay whatever lawsuit settlements come from the deaths, and when it’s better to recall the cars because the number of deaths will result in too many lawsuits? This is humanitarian do-gooder stuff compared to the savage real-world fraud-for-profit model that drives America’s drug companies. It’s really simple and it goes like this: the more fraud a drug company commits, so long as it’s off-the-scale fraud with the most horrible consequences for the victims, the drug company’s profits always outdo the criminal fines and lawsuits by factors of 20, 30, 100… It’s as simple as that.
And that's not the only way science can go awry. In his seminal paper "Why Most Published Research Findings Are False," Stanford professor John Ioannidis (see the Atlantic article "Lies, damned lies and medical science" that explains this) developed a mathematical model to show how broken the research process is. Researchers run badly designed and biased experiments, too often focusing on sensational and unlikely theories instead of ones that are likely to be plausible. That ultimately distorts the evidence base — and what we think we know to be true in fields like health care and medicine.
August 27, 2014 Press Release, “Statement of William W. Thompson, Ph.D., Regarding the 2004 Article Examining the Possibility of a Relationship Between MMR Vaccine and Autism”
”The omitted data suggested that African American males who received the MMR vaccine before age 36 months were at increased risk for autism. Decisions were made regarding which findings to report after the data were collected, and I believe that the final study protocol was not followed”.
Editor In Chief Of World’s Best Known Medical Journal: Half Of All The Literature Is False
“It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor of the New England Journal of Medicine”
Four pharmaceutical companies paid more than half of the $19.8 billion in civil and criminal settlements the last 20 years for improper billings to federal and state governments, according to a report Thursday by Public Citizen’s Health Research Group.
“Step aside, defense industry, there’s a new defrauder in town,” the group said on its Web site with the release of a 35–page report.
"We are trained to misinform," says whistle-blower-turned-activist Gwen Olsen
"After her niece’s early death, Olsen left the industry and went on to write ‘Confessions of an RX drug pusher’, in which she details how sales reps and doctors are complicit in destroying the lives of vulnerable people. Almost half of all Americans take at least one prescription drug, and last year, a record four billion prescriptions were written in the States. In comparison with other developed Western countries, North America is off the scale. Are all of these drugs needed? Of course not. Like everything else, it’s all about the money."
Merck's misconduct includes...misusing Pharmasset's confidential information..., and lying under oath at deposition and trial. — Federal Judge Beth Labson Freeman
It’s also an enormous black eye for Merck, whose activities the judge said consisted of “systematic and outrageous deception in conjunction with unethical business practices and litigation misconduct.”
But the case does more than raise questions about the integrity of a huge corporation. It’s a window into the extent to which the nation’s overworked patent inspectors can be misled by applicants backed by big corporate war chests in pursuit of billions of dollars in potential profits.
Legal experts have wrestled with that issue for years. “Catching fraud or other forms of cheating in the patent process is unlikely given the practical limits of the U.S. Patent and Trademark Office,” T. Leigh Anenson and Gideon Mark of the University of Maryland wrote in a 2013 law review article.
The death of medical ethics in America: “Ye cannot serve God and mammon”
"In other words, the fact that morcellation AVOIDABLY spreads and upstages deadly uterine cancers in a minority, one in 200-500, unsuspecting American women is justifiable because it financially benefits society."
According to Science Times, the Tuesday science section in The New York Times, scientific retractions are on the rise because of a "dysfunctional scientific climate" that has created a "winner-take-all game with perverse incentives that lead scientists to cut corners and, in some cases, commit acts of misconduct."
But elsewhere, audacious, falsified research stands unretracted - including the work of authors who actually went to prison for fraud.
What they don't teach in Med School: Doctors who commit malpractice must then get elected to the state legislature so they can repeal laws named after their dead patients.
"Senator Dr. Larry Stutts (R-Sheffield) has offered SB289, which would repeal a woman’s legal right to remain in the hospital for 48 hours after a normal live birth and 96 hours if the birth was cesarean or presented complication. His bill would also repeal State law requiring physicians to notify woman in writing that her mammogram showed dense tissue that may mask breast cancer.
Rose Church, a 36-year-old registered nurse from Haleyville, gave birth to a healthy baby girl on December 1, 1998. After 36 hours she was released from the hospital only to return around 36 hours later due to sessile bleeding that required four units of blood. She was again discharged only to die approximately 36 hours later of a heart attack, according to the report. Her autopsy revealed that Church had placental tissue still inside her womb, 11 days after she delivered her daughter Logan Rose.
Stutts was her OB/GYN and was named in the wrongful death suit filed by her husband Gene Church. The suit states, among other things, that Rose Church was released from the hospital despite the fact that she “was suffering from placenta accreta and continued to display persistent tachycardia.”
Her husband told the Tuscaloosa News in 1999, “If the legislation had been law last year my wife would have stayed in the hospital for 48 hours and the blood test would have shown she was having problems before she was discharged.”
"Klenner's paper (Klenner FR. The treatment of poliomyelitis and other virus diseases with vitamin C. J. South. Med. and Surg., 111:210-214, 1949.) on curing 60 cases of polio in the epidemic of 1948 should have changed the way infectious diseases were treated but it did not." - Robert Cathcart
The proof is in the Ebola pudding. There's some good reasons why a supposedly "discredited" medical protocol invented by a two time Nobel prize winner, that could not exist without his creation of the fields of molecular biology and biochemistry was more than a little helpful during the virus outbreak.
An example of the vilification of this can be shown in an episode of House where the character separate to prove C works, cheats and lies to get funding to prove it works. But the thing is it does work, we already know that, see above.
In actual facts they are what psychologists call "projecting" - this is exactly what industry did to Pauling, vilifying him during the time he was working toward his second Nobel for humanitarian work. The decision to use vaccine technology instead of molecular biology was made for economic reasons and not scientific ones.
Young breast cancer patients with faulty BRCA genes have the same survival chances as those without, a study has found.
The study, published in The Lancet Oncology, found 12% of 2,733 women aged 18 to 40 treated for breast cancer at 127 hospitals across the UK between 2000 and 2008 had a BRCA mutation.
The women's medical records were tracked for up to 10 years.
During this time, 651 of the women died from breast cancer, and those with the BRCA mutation were equally likely to have survived at the two-, five- and 10-year mark as those without the genetic mutation.
This was not affected by the women's body mass index or ethnicity.
About a third of those with the BRCA mutation had a double mastectomy to remove both breasts after being diagnosed with cancer. This surgery did not appear to improve their chances of survival at the 10-year mark.
Association of Compensation From the Surgical and Medical Device Industry to Physicians and Self-declared Conflict of Interest
A bibliometric analysis of the 100 physicians receiving the highest compensation from 10 large surgical and medical device manufacturers used payment information from the Centers for Medicare & Medicaid Services Open Payments Database. Conflicts of interest were declared by the authors in only 84 of 225 of the relevant 2016 publications (37.3%).