rs79.vrx.palo-alto.ca.us

1963 Dornhorst

1964 Sapp

1966 Brookes

1969 Kabir

1981 Mohan

1990 Garg

2007 Sahoo

2008 Collins

2009 Zaki

2014 Biwas

2015 Dusunen

2015 Guardian

2015 Maxwell

2017 Bogaczewicz

2020 Gold

1963 Dornhorst CHLOROQUINE PSYCHOSIS? 1964 Sapp Toxic Psychosis Due to Quinacrine and Chloroquine PSYCHOSIS that occurs during quinacrine hydrochloride administration has long been recognized as an infrequent but important toxic manifestation of this drug. It has only recently been noted that a toxic psychosis can be produced by chloroquine phosphate. Two patients have been seen at North Carolina Memorial Hospital who developed a toxic psychosis following administration of these antimalarial agents. 1966 Brookes Chloroquine Psychosis 1969 Kabir Chloroquine psychosis 1981 Mohan Chloroquine Psychosis: A Chemical Psychosis? Psychotic states are mimicked by the use of many drugs including amphetamines, cannabis, lysergic acid diethylamide, psilocybin, mescaline, isoniazid, and L-dopa. A paranoid psychotic picture in a clear sensorium is characteristic of amphetamine psychosis. In developing countries, malaria among other diseases is a frequent indicator of chloroquine administration. The present communication reports a series of chloroquine-induced psychosis in a clear sensorium simulating affective illness, such as mania, mixed affective states, or depression. The psychosis disappeared after cessation of the drug, combined with or without the use of low dosage phenothiazines in excited patients. From our cases, two types of presentation of chloroquine psychosis could be seen: (1) psychic with clear sensorium, mood changes, alteration in motor activity, delusions, and hallucinations; and (2) psycho-organic with clouded sensorium, disorientation, and fleeting hallucinations. The precise nature of the mechanism of the psychosis is not clear because of the limited number of reported cases. 1990 Garg Toxic Psychosis Due to Chloroquine- Not Uncommon in Children Toxic psychosis due to Chloroquine is a relatively uncommon occurrence in childhood. This entity must be kept in differential diagnosis in a case of unexplained psychosis, before resorting to a sophisticated array of detailed investigations. The purpose of this is to familiarize pediatricians with this relatively uncommon entity. The authors encountered four cases of psychosis with a wide variety of symptomatology over a period of the past 18 months. 2007 Sahoo Chloroquine-induced recurrent psychosis. Chloroquine is a commonly prescribed antimalarial drug that is widely used for the presumptive treatment of malaria in India. It has rarely been reported to cause psychosis, and to the best of our knowledge, recurrent psychosis due to chloroquine use has been reported only once, in 1996. We are reporting the second case of chloroquine-induced recurrent psychosis. We also discuss some of the possible neurobiological mechanisms leading to this neurotoxic adverse effect and our recommendations for future use of this drug. 2008 Collins Chloroquine Psychosis Masquerading as PCP: A Case Report Chloroquine and its derivatives have been drugs of choice in the prophylaxis and treatment of malaria for over 50 years. These drugs are also frequently used in the treatment of various rheumatologic disorders. Because many Americans now travel abroad and may require chloroquine prophylaxis, as well as the fact that such medications are readily available through Internet-based supply houses, clinicians should be aware of the potential toxicity associated with the use of these agents. We present the case of an adolescent female who presented with acute, chloroquine-induced toxic psychosis resembling that induced by phencyclidine (PCP) in clinical presentation and laboratory findings. In the acute setting, the differentiation between chloroquine toxic psychosis and PCP psychosis may be difficult. Therefore, the syndrome of chloroquine-induced psychosis is reviewed and its differentiation from PCP psychosis highlighted as it relates to important aspects of this case.

2009 Zaki Toxic psychosis due to chloroquine overdose : a case report Malaria is an endemic disease in developing countries like India. Peripheral smear examination for malarial parasites, though the gold standard for diagnosis is observer-dependent and may be reported as negative even in strongly-suspected cases. Hence, a large number of patients having fever are empirically treated with antimalarial drugs. Chloroquine and its derivatives have been the drugs of choice in the prophylaxis and treatment of uncomplicated malaria for over many years. Common side-effects of chloroquine are nausea, vomiting and unpleasant taste. Central nervous system adverse events following chloroquine have been described1–4. We herein report a child who developed psychosis following chloroquine overdose. 2014 Biwas Psychosis following chloroquine ingestion: a 10-year comparative study from a malaria-hyperendemic district of India Serious adverse effects such as acute psychoses have been reported following treatment with chloroquine. Chloroquine can cause cell death, including neurons. We aimed to identify the most frequent type of psychiatric manifestation and symptomatological characteristics of psychosis following chloroquine ingestion 2015 Dusunen Hydroxychloraquine-induced acute psychotic disorder in a female patient with rheumatoid arthritis: a case report Chloroquine and its derivative hydroxychloroquine (HCQ) have been used for acute and prophilactic treatment of malaria for most of the last century. HCQ has anti-inflammatory, antilipidemic and antithrombotic effects and in recent years has become an important drug for treating rheumatoid arthritis (RA). In the literature, antimalarial-induced psychosis has been reported in a small number of cases; however, we did not find any case related with HCQ-induced psychosis in rheumatoid arthritis. We want to report a 73-year-old female RA patient without a previous history of psychosis who developed psychosis after use of HCQ. HCQ is being increasingly prescribed in autoimmune diseases. Clinicians need to be aware of psychosis as a rare but debilitating side effect. 2015 Guardian Experience: my anti-malaria drugs made me psychotic ‘I felt I knew God, and that I was his second son. I began writing a new religion, a mixture of Christianity, Islam and my own reflections. I’d never been so excited’ 2015 Maxwell Prolonged neuropsychiatric effects following management of chloroquine intoxication with psychotropic polypharmacy Susceptibility to quinoline antimalarial intoxication may reflect individual genetic and drug-induced variation in neuropharmacokinetics. In this report, we describe a case of chloroquine intoxication that appeared to be prolonged by subsequent use of multiple psychotropic medications. This case highlights important new considerations for the management of quinoline antimalarial intoxication. 2017 Bogaczewicz Psychiatric adverse effects of chloroquine Chloroquine is a prototype antimalarial drug, widely used in several branches of medicine. Antimalarial drugs are used in the treatment of various dermatological, immunological, rheumatological and infectious diseases. Examples of off-labelled indications for chloroquine analogues use include dermatomyositis, sarcoidosis, polymorphous light eruption, disseminated granuloma annulare and porfiria cutanea tarda. There is a relatively small number of adverse effects related to chloroquine analogues used in standard doses, such as gastrointestinal disturbances, headaches, skin reactions, hypotension, convulsions, extrapyramidal symptoms and visual disturbances. Psychiatric side effects of chloroquine seem to be rare, but may manifest in a wide range of symptoms, such as confusion, disorientation, ideas of persecution, agitation, outbursts of violence, loss of interest, feeling sad, suicidal ideas and impaired insight. There is also a report of a manic episode with psychotic features in the course of bipolar disorder, and another case report of persecutory delusions, anxiety, derealisation and visual illusions triggered by chloroquine. The duration of psychiatric symptoms usually ranges from one to two weeks, and symptoms usually disappear within several days following cessation of chloroquine usage and starting psychiatric treatment where indicated. This article reviews the case studies of patients diagnosed with mental disorders resulting from the use of chloroquine, and discusses the management in such cases. 2020 Gold No, These Medicines Cannot Cure Coronavirus - As psychiatrists, we are worried about the shocking increase in people self-medicating with unsafe drugs. As psychiatrists, we are worried about the shocking increase in people self-medicating with these drugs. To emphasize this point: These are not harmless medications. They could have serious consequences — like death. That’s not theoretical. An Arizona man died (and his wife is in critical condition) after ingesting chloroquine phosphate, which in one formulation is sold to clean fish tanks. Similar overdoses have been reported internationally.