rs79.vrx.palo-alto.ca.us
Ebola, Selenium and the Virus.
Ebola, Selenium and the Virus in General

In 1976 Ebola first broke out and a strange immunity to the disease was first noticed[1]. This was noticed with every infection and in 2010 the Pasteur Institute did an immunoassay of every tenth person in Gabon[2] and noticed up to 33% immunity; that is up to a third showed antibodies indicating they had had the disease but not a single person got sick or suffered any symptoms whatsoever.

Taylor[3] in 1995 proposed a hypothesis but it was Lipinski at Harvard in 2015 that published on the biochemistry of the mysterious Ebola immunity.[4] The surprise is that it works on all enveloped viruses (which is nearly all of them) yet industry ignores this and presses on with a horrendously expensive and hard to make vaccine that does not actually work. It provides some protection for "eleven days". Ebola makes you sick on the tenth day so these are misleading stats. Selenium inhibits the disulfide bond the virus must initially make with the cellular membrane of the host cell; absent this bond the virus is unable to enter and infect the cell. Inhibit that initial bond, you inhibit the virus.

The outbreaks are easy to explain. The virus is always there and never found in ares of low selenium. As long as serum selenium is high enough they're immune. The problem is logging. Nuts provide the mineral and they're valuable. It's predictable that if they remove Fika/Tiger nut trees unless there is another daily dietary source of selenium, it's only a mater of time before Ebola breaks out.

The national dish of the area is a chicken nut curry. Twice a year Fika nuts are harvested and a nut paste is made and eaten daily[5]. Ebola always breaks out right before the harvest if you notice. Fika nuts also known as Gabon nuts and the related tiger nut are the same as Brazil nuts. Two a day will optimize selenium and glutathione levels in 12 weeks[6].

[1] "The phenomenon of previously undetected, minimally symptomatic EBOV infection was evident around the discovery of the virus in 1976."
Richardson 2016 - Minimally Symptomatic Infection in an Ebola ‘Hotspot’: A Cross-Sectional Serosurvey
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005087

[2] Becquart_2010 - High Prevalence of Both Humoral and Cellular Immunity to Zaire ebolavirus among Rural Populations in Gabon
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009126
http://en.ird.fr/the-media-centre/scientific-newssheets/337-possible-natural-immunity-to-ebola
http://www.nytimes.com/2014/09/06/health/ebola-immunity.html

[3] Theoretical Evidence that the Ebola Virus Zaire Strain May Be Selenium-Dependent: A Factor in Pathogenesis and Viral Outbreaks?
http://orthomolecular.org/library/jom/1995/articles/1995-v10n0304-p131.shtml>http://orthomolecular.org/library/jom/1995/articles/1995-v10n0304-p131.shtml

[4] "It is known that the virulence of Ebola and other RNA enveloped viruses involves in the first step their attachment to host cell membranes. Following this initial step the virus enters the target cell cytoplasm by forming hydrophobic spikes that make holes in the membrane lipid bilayer. Formation of such spikes is catalyzed by the reduced form of viral protein disulfide isomerase (PDIred) thus initiating chain of disulfide exchange reactions. Consequently, hydrophobic protein epitopes become exposed, which in the absence of proper chaperones form hydrophobic ‘spikes’ capable of penetrating the host cell membranes.
In this communication evidence is discussed showing that the chain of disulfide exchange events can be inhibited by a small redox molecule – sodium selenite.
It is suggested that this inexpensive and readily available food supplement can be an ultimate inhibitor of Ebola and other enveloped viral infections.
http://www.journalrepository.org/media/journals/BJMMR_12/2014/Dec/Lipinski632014BJMMR14858.pdf

[5] BBC Baka - A Cry From the Rainforest
https://www.youtube.com/watch?v=8dgSWdSfFJA 11:00 27:36

The fruit has two forms (a dry season form and rainy season form) and has many names; as a paste the nuts last 6+ months. The word "Feka" means "fruit" in The Jewish Neo-Aramaic Dialect of Challa.

Coula edulis: Gabon Nut, African Walnut, Congowood, Tigerwood
http://en.wikipedia.org/wiki/Coula_edulis


Irvingia gabonensis: Wild mango, African mango, bush mango, dika or ogbono
http://en.wikipedia.org/wiki/Irvingia_gabonensis


Se Foods: NIH list of Selenium containing foods
http://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/


Se Nuts: Nutrients and bioactive compounds content of Baillonella toxisperma, Trichoscypha abut and Pentaclethra macrophylla from Cameroon
http://onlinelibrary.wiley.com/doi/10.1002/fsn3.217/full


close: Close but no cigar
http://anhinternational.org/2014/10/15/anh-intl-feature-musings-on-ebola-a-case-for-immune-modulation-therapy/


nsf: NSF nutrition database
http://nutritiondata.self.com/foods-000127000000000000000-w.html


recipe: Gabon: Nyembwe Chicken with Gabon Nuts
http://foodandculturerecipes.blogspot.ca/2010/10/gabon-nyembwe-chicken_752.html


[6] "Not only was consumption of two Brazil nuts each day as effective for increasing selenium status and enhancing GPx activity as 100 micrograms of selenomethionine per day, but just one Brazil nut per day would have been sufficient to raise dietary selenium intake to within recommended intake levels for the mineral."
Brazil nuts: an effective way to improve selenium status
http://ajcn.nutrition.org/content/87/2/379.full

history

EBOV timeline


life-cycle



refs

In 1995 Se was theorized to kill EBOV

A 1995 paper pointed out the Ebola virus encodes for selenium and might be killed by it.

In 1976 and in every outbreak since then we have known there have been people that did not catch Ebola and others that did not get sick if they did become infected.

By 2007 we know why, by 2015 we knew how.

The good news is it also protects against all other highly pathogenic developed viruses, this negating the need for vaccines for this, which is good because so far their performance has been very poor in all cases.


remediation


summary

The vaccine will not work well or at all. It may program the immune system to produce antibodies but if they cannot manufacture glutathione peroxidase thy will not be able to do their job.

It does not do a sick patient much good, we know this, nor does it save that many lives, the virus disables the immune system and telling the immune system how to kill the virus with the chemicals the virus just used all up is pointless. It's entirely the wrong approach.

Clearly the ZEBOV-immune Gabonese villagers do not have a triple recombinant reverse transcriptase inhibitor vaccine now do they? They get the same thing by eating fruit. The just have better fruit than we do.

What is in the fruit they eat? (selenium)

Does this correlate with what science knows about the mechanics of selenovirus replication? Yes, absolutely.

High selenium level is the key to stopping the pathogenic African strains, rendering them as inert as Ebola Reston. Serum Ascorbate level determines symptoms; if high enough no symptoms should be reported, at improper ascorbate levels some incidence of "the sniffles" may occur.


This NYT article is now a decade old. A lot happened since then. Like the 2014 outbreak. The problem with Ebola is, you can't study it very often. And it usually kills all the doctors and nurses as it did in West Africa.

As of four years ago now western medicine know. Had you wondered by Ebola, which is 99% fatal, did not kill any of the six US/UK citizens on their home turf that had the disease? Not one of six died of a diseae 99% fatal. Why?

The people who are immune (note that this article and the IRD press release [1] from the Pasteur Institute in France published [2] reference a PLOS paper about the Pasteur Institute immunoassay of every tenth person in Gabon for ZEBOV ("Ebola Zaire") antibodies. Up to 30% of the inhabitants of the coastal forest have the antibody, but not one ever had any symptoms. Asymptotic patients have been known since the first outbreak in 1976[3]; this is what the NYT article above says.)

In 1995 Taylor [4] pointed out UGG codons in the viral rna sequester selenium, that's how it kills you so fast, it first takes out your immune system by dong this; Ebola does this in a day, HIV takes 10 years but does the same thing.

There are many articles that talk about the role of Se in EBOV, #Lipinski_2015 was able to figure out how this works [5] and a couple of Brazil nut a day (the highest source known) will do it. Better yet, Lipinski points out this works on "all enveloped viruses". The BAKA poeple[6] of Gabon eat Fika nuts daily, they are the same nut under a different name, also called Gabon nut; the national dish of Gabon is chicken curry made with Gabon nuts. [7][8]]

Selenite pills work as well and are cheap (Vitamin Aisle). By now all my good friends take two brazil nuts a day. They say they don't get sick as often. Plus they're immune to Ebola now too.

[1] http://en.ird.fr/the-media-centre/scientific-newssheets/337-possible-natural-immunity-to-ebola

[2] Becquart 2010 - High Prevalence of Both Humoral and Cellular Immunity to Zaire ebolavirus among Rural Populations in Gabon http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009126

[3] "active circulation of filovirus without apparent clinical manifestations" http://rs79.vrx.palo-alto.ca.us/opinions/ideas/pharma/ortho/06_ebola/refs/gabon/papers/Gonzales_2000/gonzalez2000.pdf

[4] Theoretical Evidence that the Ebola Virus Zaire Strain May Be Selenium-Dependent: A Factor in Pathogenesis and Viral Outbreaks? http://orthomolecular.org/library/jom/1995/articles/1995-v10n0304-p131.shtml

[5] http://www.journalrepository.org/media/journals/BJMMR_12/2014/Dec/Lipinski632014BJMMR14858.pdf

[6] https://www.youtube.com/watch?v=WKRIkkmy39w

[7] http://foodandculturerecipes.blogspot.ca/2010/10/gabon-nyembwe-chicken_752.html

[8] Brazil nuts: an effective way to improve selenium status "Not only was consumption of two Brazil nuts each day as effective for increasing selenium status and enhancing GPx activity as 100 micrograms of selenomethionine per day, but just one Brazil nut per day would have been sufficient to raise dietary selenium intake to within recommended intake levels for the mineral." http://ajcn.nutrition.org/content/87/2/379.full

A Review of Dietary Selenium Intake and Selenium Status in Europe and the Middle East, 2015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377864/

See also http://en.wikipedia.org/wiki/Keshan_disease

"29 Jan 2015 - Liberia: Harvard Scientist Claims Selenium Can Treat Ebola" https://allafrica.com/stories/201501291709.html "29 January 2015 Last updated at 00:55 - We've now seen several cases that don't have any symptoms at all, asymptomatic cases," said Anavaj Sakuntabhai who suggested the virus might be mutating. http://www.bbc.com/news/health-31019097 British nurse cured of Ebola credits new drug - and strawberries "Back in Britain, the decision to try MIL 77 was not difficult. “I said ‘I have Ebola, so, yes, I’d rather have that than high-dose vitamin C,’” she said" "“I reckon I’ve had 10 punnets,” joked Corporal Anna Cross, who smiled nervously as she talked for the first time after her treatment at the Royal Free Hospital in north London." (10 punnets would be about equal to two 1000mg injections a day)

Why the need for C if the vaccine works?

See Marik 2017, that's why.

http://www.telegraph.co.uk/news/worldnews/ebola/11499584/Nurse-who-became-first-in-world-to-be-cured-of-Ebola-by-experimental-drug-is-discharged.html
April 2015 - semen found infected after 175 days, twue the previous record.
http://io9.com/ebola-survivors-are-being-urged-to-abstain-from-sex-1698996342
The Ebola outbreak in Liberia is over
9 May 2015 -- Today marks 42 days since the last confirmed case of Ebola in Liberia was safely buried — the period of time set by WHO to declare an outbreak over. WHO now considers Liberia free of Ebola transmission.
http://apps.who.int/ebola/liberias-success-in-ending-ebola
Wednesday, May 13, 2015 - Ebola Not Mutating Beyond 'Normal' Rate, Scientists Say
http://www.nlm.nih.gov/medlineplus/news/fullstory_152522.html
28 May 2015 | Did real-time epidemic modeling save lives in West Africa?
http://spectrum.ieee.org/computing/software/how-computer-modelers-took-on-the-ebola-outbreak