Altered Virulence of Vaccine Strains of Measles Virus after Prolonged Replication in Human Tissue
"...Prior to pursuing the genetic characterization of potential virulent revertants, we investigated whether such phenotypic reversion occurs. In these studies, we have characterized an MV strain recovered after prolonged growth of Moraten in a thy/liv implant (pMor-1 [passaged Moraten]) and have investigated whether Hu2, an MV strain isolated from a child with congenital immunodeficiency who died of disseminated measles after immunization with the Schwarz vaccine (12), has enhanced virulence in thy/liv implants. Both strains showed increased virulence in the thy/liv model. The identification of genetically related strains that differ in virulence provides a basis for the elucidation of sequences that govern MV virulence."
"Methylmercury in vaccines, might exceed safe levels."
Scientific Review of Vaccine Safety Datalink Information
June 7-8, 2000 Simpsonwood Retreat Center Norcross, Georgia
Dr. Orenstein:My name is Walter Orenstein. I'm Director of the National
Immunization Program at CDC and I want to thank all of you for coming here
and taking time out of your very busy schedules to spend the next day and a
half with us. Not only do we thank you for taking time out, but for taking the
time out on such short notice, and also putting up with what I gather those of us
who are townies here didn't realize, but apparently the biggest meeting in
Atlanta which has taken up all the hotel space and all of the cars, so I think
many of you have had to take taxis here. We appreciate you putting up with
this, but at least we did arrange the weather nicely and you can look out
occasionally and see some beautiful trees. I think I am particularly impressed
with the quality of expertise. We truly have been able to get at very short notice
some of the most outstanding leaders in multiple fields. That will be important
in interpreting the data. We who work with vaccines take vaccine safety very
seriously. Vaccines are generally given to healthy children and I think the
public has, deservedly so, very high expectations for vaccine safety as well as
the effectiveness of vaccination programs. Those who don't know, initial
concerns were raised last summer that mercury, as methylmercury in vaccines,
might exceed safe levels. As a result of these concerns, CDC undertook, in
collaboration with investigators in the Vaccine Safety Datalink, an effort to
evaluate whether there were any health risks from mercury in any of these
See also this summary of this conference
Historical Vaccine Safety Concerns
- Simian Virus 40 (SV40) - 1955–1963
- Swine Flu Vaccine and Guillain-Barré Syndrome - 1976
- Hepatitis B Vaccine and Multiple Sclerosis – 1998
- Rotavirus Vaccine and Intussusception – 1998 - 1999
- Guillain-Barré Syndrome and Meningococcal Vaccine - 2005 – 2008
- Hib Vaccine Recall – 2007
- H1N1 Influenza Vaccine and Narcolepsy - 2009 – 2010
- Porcine Circovirus in Rotavirus Vaccines - 2010
- HPV Vaccine Recall – 2013
Sudden infant death syndrome (SIDS) shortly after hexavalent vaccination: another pathology in suspected SIDS?
Experts from panels of the European Agency for the Evaluation of Medical Products have investigated whether there might be a link between hexavalent vaccines and some cases of deaths that occurred. Participants included pathologists with experience in the field of vaccines and sudden infant death syndrome who conducted autopsies. However, to the best of our knowledge, little, if any, attention was paid to examination of the brainstem and the cardiac conduction systems on serial sections, nor was the possibility of a triggering role of the vaccine in these deaths considered. Herein we report the case of a 3-month-old female infant dying suddenly and unexpectedly shortly after being given a hexavalent vaccination. Examination of the brainstem on serial sections revealed bilateral hypoplasia of the arcuate nucleus. The cardiac conduction system presented persistent fetal dispersion and resorptive degeneration. This case offers a unique insight into the possible role of hexavalent vaccine in triggering a lethal outcome in a vulnerable baby. Any case of sudden unexpected death occurring perinatally and in infancy, especially soon after a vaccination, should always undergo a full necropsy study according to our guidelines.
Risk of death from flu increases proportionally with frequency of flu shots.
The more flu shots you have the greater the chance of dying from the flu.
We understood a certain rate of death from flu, then vaccinated 80% of the population.
Deaths from flu now occur at a higher rate, and among the elderly the more flu shots you've had the greater the chance you'll die of flu.
That is, after a decade of flu shots, and over time as we vaccinated nearly everyone, more people died of flu than before.
The "neutral third party" boards that make vaccine guidelines are funded by vaccine producers.
How Independent Are Vaccine Defenders?
BY SHARYL ATTKISSON
JULY 25, 2008 / 6:20 PM / CBS
They're some of the most trusted voices in the defense of vaccine safety: the American Academy of Pediatrics, Every Child By Two, and pediatrician Dr. Paul Offit.
But CBS News has found these three have something more in common - strong financial ties to the industry whose products they promote and defend.
The vaccine industry gives millions to the Academy of Pediatrics for conferences, grants, medical education classes and even helped build their headquarters. The totals are kept secret, but public documents reveal bits and pieces.
A spokesman told CBS News: "There are simply no conflicts to be unearthed." But guess who's listed as the group's treasurers? Officials from Wyeth and a paid advisor to big pharmaceutical clients.
Then there's Paul Offit, perhaps the most widely-quoted defender of vaccine safety.
He's gone so far as to say babies can tolerate "10,000 vaccines at once."
This is how Offit described himself in a previous interview: "I'm the chief of infectious disease at Children's Hospital of Philadelphia and a professor of pediatrics at Penn's medical school," he said.
Offit was not willing to be interviewed on this subject but like others in this CBS News investigation, he has strong industry ties. In fact, he's a vaccine industry insider.
Offit holds in a $1.5 million dollar research chair at Children's Hospital, funded by Merck. He holds the patent on an anti-diarrhea vaccine he developed with Merck, Rotateq, which has prevented thousands of hospitalizations.
And future royalties for the vaccine were just sold for $182 million cash. Dr. Offit's share of vaccine profits? Unknown.
Viral Trigger for Type 1 Diabetes. This includes vaccine derived strains.
Type 1 diabetes is a genetic autoimmune disorder caused by autoreactive CD4+ and CD8+ T-cells that recognize pancreatic antigens such as insulin or GAD and subsequently destroy insulin-producing β-cells. The subject of very active research is the question of how endogenous β-cell antigens become immunogenic. Infiltration of the islets of Langerhans, where β-cells reside, by activated autoreactive T-cells is considered to be the major driving force in type 1 diabetes progression. The islet infiltrate in humans consists primarily of CD8+ T-cells and B-cells, followed by macrophages and dendritic cells of different subtypes (1). Interestingly, significantly fewer T-cells are found in human islets compared with islets from nonobese diabetic (NOD) mice. The reduced numbers of T-cells, and in this way a limited autoreactive component in human islets, leads one to consider whether other contributing factors may be involved in disease development. Otherwise, sufficient insulitic infiltrate to destroy islet β-cells might not be easily maintained in humans. Further supporting a role for nongenetic factors in the control of type 1 diabetes is the observation that disease concordance among monozygotic twins is below 50% (2). Migrant studies also suggest the involvement of an environmental factor in type 1 diabetes, since disease incidence in migrating populations appears to conform to the incidence of the region to which there is migration (3). There is an ever-increasing body of literature suggesting that the significant environmental component to type 1 diabetes development and progression is a viral infection. However, this has not been clearly demonstrated. In fact, viral infections appear to have both detrimental and protective effects on type 1 diabetes development, which might be contingent upon the nature of the virus, but also the immune status of the host and thus the timing of infection.
A significant number of viruses have been associated with type 1 diabetes, including enteroviruses such as Coxsackievirus B (CVB) (4), but also rotavirus (5,6), mumps virus (7), and cytomegalovirus. Rubella virus has been suggested to cause type 1 diabetes, but so far only congenital rubella syndrome has conclusively been associated with the disease.
The US childhood immunization schedule specifies 26 vaccine doses for infants aged less than 1 year—the most in the world…yet 33 nations have lower IMRs [infant mortality rates].” They found that across the 34 nations analyzed “a high statistically significant correlation between increasing number of vaccine doses and increasing infant mortality rates.
The infant mortality rate (IMR) is one of the most important indicators of the socio-economic well-being and public health conditions of a country. The US childhood immunization schedule specifies 26 vaccine doses for infants aged less than 1 year—the most in the world—yet 33 nations have lower IMRs. Using linear regression, the immunization schedules of these 34 nations were examined and a correlation coefficient of r = 0.70 (p < 0.0001) was found between IMRs and the number of vaccine doses routinely given to infants. Nations were also grouped into five different vaccine dose ranges: 12–14, 15–17, 18–20, 21–23, and 24–26. The mean IMRs of all nations within each group were then calculated. Linear regression analysis of unweighted mean IMRs showed a high statistically significant correlation between increasing number of vaccine doses and increasing infant mortality rates, with r = 0.992 (p = 0.0009). Using the Tukey-Kramer test, statistically significant differences in mean IMRs were found between nations giving 12–14 vaccine doses and those giving 21–23, and 24–26 doses. A closer inspection of correlations between vaccine doses, biochemical or synergistic toxicity, and IMRs is essential.
The RRs of SUD for any vaccines and any risk periods, even when greater than 1, were almost an order of magnitude lower than the estimates in Germany. The limited increase in RRs found in Italy appears confined to the first dose and may be partly explained by a residual uncontrolled confounding effect of age.
The signal of an association between vaccination in the second year of life with a hexavalent vaccine and sudden unexpected deaths (SUD) in the two days following vaccination was reported in Germany in 2003. A study to establish whether the immunisation with hexavalent vaccines increased the short term risk of SUD in infants was conducted in Italy.
Co-administration of live measles and yellow fever vaccines and inactivated pentavalent vaccines is associated with increased mortality compared with measles and yellow fever vaccines only. An observational study from Guinea-Bissau
Results: While DTP was still used 685 children received MV only and 358 MV+DTP; following the change in programme, 940 received MV+YF only and 348 MV+YF+pentavalent. During 6 months of follow-up, the adjusted mortality rate ratio (MRR) for co-administered live and inactivated vaccines compared with live vaccines only was 3.24 (1.20-8.73). For MV+YF+pentavalent compared with MV+YF only, the adjusted MRR was 7.73 (1.79-33.4).
Conclusion: In line with previous studies of DTP, the present results indicate that pentavalent vaccine co-administered with MV and YF is associated with increased mortality.
we hypothesize that vaccine components could have a direct role in sparking off a lethal outcome in SIDS vulnerable babies
Sudden Infant Death Following Hexavalent Vaccination: A Neuropathologic Study
Are Well-Child Visits a Risk Factor for Subsequent Influenza-Like Illness Visits?
We found that an ILI office visit by a family member was positively associated with a well-child visit in the same or one of the previous 2 weeks (odds ratio, 1.54). This additional risk translates to potentially 778,974 excess cases of ILI per year in the United States, with a cost of $500 million annually.
Our results should encourage ambulatory clinics to strictly enforce infection control recommendations. In addition, clinics could consider time-shifting of well-child visits so as not to coincide with the peak of the influenza season.
Public Health Officials Know: Recently Vaccinated Individuals Spread Disease
Public Health Officials Know: Recently Vaccinated Individuals Spread Disease
Tuesday, 3 Mar 2015 | 2:41 PM ET
Washington, D.C., March 3, 2015 (GLOBE NEWSWIRE) -- Physicians and public health officials know that recently vaccinated individuals can spread disease and that contact with the immunocompromised can be especially dangerous. For example, the Johns Hopkins Patient Guide warns the immunocompromised to "Avoid contact with children who are recently vaccinated," and to "Tell friends and family who are sick, or have recently had a live vaccine (such as chicken pox, measles, rubella, intranasal influenza, polio or smallpox) not to visit."
Inactivated influenza vaccine given alone was most commonly associated with death reports in adults (51.4%).
Deaths Reported to the Vaccine Adverse Event Reporting System, United States, 1997–2013
"No concerning pattern was noted among death reports submitted to VAERS during 1997–2013. The main causes of death were consistent with the most common causes of death in the US population."
The catch here is the three most common causes of death are 1) heart, 2) cancer 3) Iatrogenesis, where the medical industry itself kills the patient.
The medical system is the third-leading cause of death in the United States (Ref: Starfield B (July 2000): "Is US health really the best in the world?" - JAMA 284 (4): 483–5. doi:10.1001/jama.284.4.483. PMID 10904513)
Immunization selects for the most pathogenic forms of a virus.
Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek's disease virus enhances the fitness of more virulent strains, making it possible for hyperpathogenic strains to transmit. Immunity elicited by direct vaccination or by maternal vaccination prolongs host survival but does not prevent infection, viral replication or transmission, thus extending the infectious periods of strains otherwise too lethal to persist. Our data show that anti-disease vaccines that do not prevent transmission can create conditions that promote the emergence of pathogen strains that cause more severe disease in unvaccinated hosts.
here is a theoretical expectation that some types of vaccines could prompt the evolution of more virulent (“hotter”) pathogens. This idea follows from the notion that natural selection removes pathogen strains that are so “hot” that they kill their hosts and, therefore, themselves. Vaccines that let the hosts survive but do not prevent the spread of the pathogen relax this selection, allowing the evolution of hotter pathogens to occur. This type of vaccine is often called a leaky vaccine. When vaccines prevent transmission, as is the case for nearly all vaccines used in humans, this type of evolution towards increased virulence is blocked. But when vaccines leak, allowing at least some pathogen transmission, they could create the ecological conditions that would allow hot strains to emerge and persist. This theory proved highly controversial when it was first proposed over a decade ago, but here we report experiments with Marek’s disease virus in poultry that show that modern commercial leaky vaccines can have precisely this effect: they allow the onward transmission of strains otherwise too lethal to persist. Thus, the use of leaky vaccines can facilitate the evolution of pathogen strains that put unvaccinated hosts at greater risk of severe disease. The future challenge is to identify whether there are other types of vaccines used in animals and humans that might also generate these evolutionary risks.
"DTP vaccinations were associated with increased infant mortality even though there was no vaccine-induced herd immunity."
The Introduction of Diphtheria-Tetanus-Pertussis and Oral Polio Vaccine Among Young Infants in an Urban African Community: A Natural Experiment.
We examined the introduction of diphtheria-tetanus-pertussis (DTP) and oral polio vaccine (OPV) in an urban community in Guinea-Bissau in the early 1980s.
The child population had been followed with 3-monthly nutritional weighing sessions since 1978. From June 1981 DTP and OPV were offered from 3 months of age at these sessions. Due to the 3-monthly intervals between sessions, the children were allocated by birthday in a ‘natural experiment’ to receive vaccinations early or late between 3 and 5 months of age. We included children who were < 6 months of age when vaccinations started and children born until the end of December 1983. We compared mortality between 3 and 5 months of age of DTP-vaccinated and not-yet-DTP-vaccinated children in Cox proportional hazard models.
Among 3–5-month-old children, having received DTP (± OPV) was associated with a mortality hazard ratio (HR) of 5.00 (95% CI 1.53–16.3) compared with not-yet-DTP-vaccinated children. Differences in background factors did not explain the effect. The negative effect was particularly strong for children who had received DTP-only and no OPV (HR = 10.0 (2.61–38.6)). All-cause infant mortality after 3 months of age increased after the introduction of these vaccines (HR = 2.12 (1.07–4.19)).
DTP was associated with increased mortality; OPV may modify the effect of DTP.
Association of American Physicians and Surgeons Statement against Federal Vaccine Mandates
Association of American Physicians and Surgeons
"Vaccines are neither 100% safe nor 100% effective. Nor are they the only available means to control the spread of disease."
"The last measles death in the U.S. occurred in 2015"
To: Oversight and Investigations Subcommittee, House Energy and Commerce Committee
Senate Committee on Health, Education, Labor and Pensions
Re: Statement federal vaccine mandates
Feb. 26, 2019
Jane M. Orient, M.D., Executive Director
Association of American Physicians and Surgeons
"... Vaccines are necessarily risky, as recognized by the U.S. Supreme Court and by Congress. The Vaccine Injury Compensation Program has paid some $4 billion in damages, and high hurdles must be surmounted to collect compensation. The damage may be so devastating that most people would prefer restored function to a multimillion-dollar damage award.
The smallpox vaccine is so dangerous that you can’t get it now, despite the weaponization of smallpox. Rabies vaccine is given only after a suspected exposure or to high-risk persons such as veterinarians. The whole-cell pertussis vaccine was withdrawn from the U.S. market, a decade later than from the Japanese market, because of reports of severe permanent brain damage. The acellular vaccine that replaced it is evidently safer, though somewhat less effective.
The risk: benefit ratio varies with the frequency and severity of disease, vaccine safety, and individual patient factors. These must be evaluated by patient and physician, not imposed by a government agency..."
"...vaccines can also have non-specific effects on unrelated infections and diseases, with important implications for childhood mortality particularly in low-income setting"
The textbook view of vaccination is that it functions to induce immune memory of the specific pathogen components of the vaccine, leading to a quantitatively and qualitatively better response if the host is exposed to infection with the same pathogen. However, evidence accumulated over the past few decades increasingly suggests that vaccines can also have non-specific effects on unrelated infections and diseases, with important implications for childhood mortality particularly in low-income settings. Furthermore, many of these non-specific effects, as well as the pathogen-specific effects, of vaccines show differences between the sexes. Here, members of the Optimmunize consortium discuss the evidence for and potential mechanisms of non-specific and sex-differential effects of vaccines, as well as their potential policy implications. Given that the non-specific effects of some vaccines are now being tested for their ability to protect against COVID-19, the authors also comment on the broader implications of these trials.
Vaccinated kids are sicker than unvaccinated kids.
Analysis of health outcomes in vaccinated and unvaccinated children: Developmental delays, asthma, ear infections and gastrointestinal disorders
Vaccination before 1 year of age was associated with increased odds of developmental delays (OR = 2.18, 95% CI 1.47–3.24), asthma (OR = 4.49, 95% CI 2.04–9.88) and ear infections (OR = 2.13, 95% CI 1.63–2.78). In a quartile analysis, subjects were grouped by number of vaccine doses received in the first year of life. Higher odds ratios were observed in Quartiles 3 and 4 (where more vaccine doses were received) for all four health conditions considered, as compared to Quartile 1. In a temporal analysis, developmental delays showed a linear increase as the age cut-offs increased from 6 to 12 to 18 to 24 months of age (ORs = 1.95, 2.18, 2.92 and 3.51, respectively). Slightly higher ORs were also observed for all four health conditions when time permitted for a diagnosis was extended from ⩾ 3 years of age to ⩾ 5 years of age.
Paradoxically some vaccines make viruses worse
Vaccines save millions of lives every year by teaching our immune systems how to combat certain viruses or bacteria. But a new study suggests that, paradoxically, they could sometimes teach pathogens to become more dangerous as well.
The article cites Read's 2015 paper.
CIA Says It Will No Longer Use Vaccine Programs As Cover
A White House official says the CIA will no longer use vaccine programs as cover for spy operations, answering health experts' complaints that it had hurt international efforts to fight disease.
The CIA famously used a vaccination program as a ploy to gain information about the possible whereabouts of Osama bin Laden in Pakistan. That effort didn't succeed, and the doctor involved was sentenced to a prison term. But the revelation had immediate effects — particularly in the fight against polio.
As The New York Times reported in 2012, vaccination teams were banned in some areas of Pakistan.
151 pages of just titles of medical journal article in a timeline of vaccine injuries from 1926 to 2008
Electronic Support for Public Health–Vaccine Adverse
Event Reporting System (ESP:VAERS)
Inclusive dates: 12/01/07 - 09/30/10