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Vaccines Can Increase Virus Pathogenicity
Vaccines Can Increase Virus Pathogenicity

Altered Virulence of Vaccine Strains of Measles Virus after Prolonged Replication in Human Tissue

"...Prior to pursuing the genetic characterization of potential virulent revertants, we investigated whether such phenotypic reversion occurs. In these studies, we have characterized an MV strain recovered after prolonged growth of Moraten in a thy/liv implant (pMor-1 [passaged Moraten]) and have investigated whether Hu2, an MV strain isolated from a child with congenital immunodeficiency who died of disseminated measles after immunization with the Schwarz vaccine (12), has enhanced virulence in thy/liv implants. Both strains showed increased virulence in the thy/liv model. The identification of genetically related strains that differ in virulence provides a basis for the elucidation of sequences that govern MV virulence."


Risk of death from flu increases proportionally with frequency of flu shots.

The more flu shots you have the greater the chance of dying from the flu.

We understood a certain rate of death from flu, then vaccinated 80% of the population.

Deaths from flu now occur at a higher rate, and among the elderly the more flu shots you've had the greater the chance you'll die of flu.

That is, after a decade of flu shots, and over time as we vaccinated nearly everyone, more people died of flu than before.


The "neutral third party" boards that make vaccine guidelines are funded by vaccine producers.

How Independent Are Vaccine Defenders?

BY SHARYL ATTKISSON
JULY 25, 2008 / 6:20 PM / CBS

They're some of the most trusted voices in the defense of vaccine safety: the American Academy of Pediatrics, Every Child By Two, and pediatrician Dr. Paul Offit. But CBS News has found these three have something more in common - strong financial ties to the industry whose products they promote and defend.

The vaccine industry gives millions to the Academy of Pediatrics for conferences, grants, medical education classes and even helped build their headquarters. The totals are kept secret, but public documents reveal bits and pieces.

A spokesman told CBS News: "There are simply no conflicts to be unearthed." But guess who's listed as the group's treasurers? Officials from Wyeth and a paid advisor to big pharmaceutical clients.
Then there's Paul Offit, perhaps the most widely-quoted defender of vaccine safety.
He's gone so far as to say babies can tolerate "10,000 vaccines at once."
This is how Offit described himself in a previous interview: "I'm the chief of infectious disease at Children's Hospital of Philadelphia and a professor of pediatrics at Penn's medical school," he said.
Offit was not willing to be interviewed on this subject but like others in this CBS News investigation, he has strong industry ties. In fact, he's a vaccine industry insider.
Offit holds in a $1.5 million dollar research chair at Children's Hospital, funded by Merck. He holds the patent on an anti-diarrhea vaccine he developed with Merck, Rotateq, which has prevented thousands of hospitalizations.
And future royalties for the vaccine were just sold for $182 million cash. Dr. Offit's share of vaccine profits? Unknown.

http://www.cbsnews.com/news/how-independent-are-vaccine-defenders/


Viral Trigger for Type 1 Diabetes. This includes vaccine derived strains.

Type 1 diabetes is a genetic autoimmune disorder caused by autoreactive CD4+ and CD8+ T-cells that recognize pancreatic antigens such as insulin or GAD and subsequently destroy insulin-producing β-cells. The subject of very active research is the question of how endogenous β-cell antigens become immunogenic. Infiltration of the islets of Langerhans, where β-cells reside, by activated autoreactive T-cells is considered to be the major driving force in type 1 diabetes progression. The islet infiltrate in humans consists primarily of CD8+ T-cells and B-cells, followed by macrophages and dendritic cells of different subtypes (1). Interestingly, significantly fewer T-cells are found in human islets compared with islets from nonobese diabetic (NOD) mice. The reduced numbers of T-cells, and in this way a limited autoreactive component in human islets, leads one to consider whether other contributing factors may be involved in disease development. Otherwise, sufficient insulitic infiltrate to destroy islet β-cells might not be easily maintained in humans. Further supporting a role for nongenetic factors in the control of type 1 diabetes is the observation that disease concordance among monozygotic twins is below 50% (2). Migrant studies also suggest the involvement of an environmental factor in type 1 diabetes, since disease incidence in migrating populations appears to conform to the incidence of the region to which there is migration (3). There is an ever-increasing body of literature suggesting that the significant environmental component to type 1 diabetes development and progression is a viral infection. However, this has not been clearly demonstrated. In fact, viral infections appear to have both detrimental and protective effects on type 1 diabetes development, which might be contingent upon the nature of the virus, but also the immune status of the host and thus the timing of infection.

A significant number of viruses have been associated with type 1 diabetes, including enteroviruses such as Coxsackievirus B (CVB) (4), but also rotavirus (5,6), mumps virus (7), and cytomegalovirus. Rubella virus has been suggested to cause type 1 diabetes, but so far only congenital rubella syndrome has conclusively been associated with the disease.


Public Health Officials Know: Recently Vaccinated Individuals Spread Disease

Public Health Officials Know: Recently Vaccinated Individuals Spread Disease Tuesday, 3 Mar 2015 | 2:41 PM ET Globe Newswire Washington, D.C., March 3, 2015 (GLOBE NEWSWIRE) -- Physicians and public health officials know that recently vaccinated individuals can spread disease and that contact with the immunocompromised can be especially dangerous. For example, the Johns Hopkins Patient Guide warns the immunocompromised to "Avoid contact with children who are recently vaccinated," and to "Tell friends and family who are sick, or have recently had a live vaccine (such as chicken pox, measles, rubella, intranasal influenza, polio or smallpox) not to visit."


Inactivated influenza vaccine given alone was most commonly associated with death reports in adults (51.4%).

Deaths Reported to the Vaccine Adverse Event Reporting System, United States, 1997–2013

"No concerning pattern was noted among death reports submitted to VAERS during 1997–2013. The main causes of death were consistent with the most common causes of death in the US population."

The catch here is the three most common causes of death are 1) heart, 2) cancer 3) Iatrogenesis, where the medical industry itself kills the patient.

Ref:
The medical system is the third-leading cause of death in the United States (Ref: Starfield B (July 2000): "Is US health really the best in the world?" - JAMA 284 (4): 483–5. doi:10.1001/jama.284.4.483. PMID 10904513)


Immunization selects for the most pathogenic forms of a virus.

Abstract

Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek's disease virus enhances the fitness of more virulent strains, making it possible for hyperpathogenic strains to transmit. Immunity elicited by direct vaccination or by maternal vaccination prolongs host survival but does not prevent infection, viral replication or transmission, thus extending the infectious periods of strains otherwise too lethal to persist. Our data show that anti-disease vaccines that do not prevent transmission can create conditions that promote the emergence of pathogen strains that cause more severe disease in unvaccinated hosts.

Author Summary

here is a theoretical expectation that some types of vaccines could prompt the evolution of more virulent (“hotter”) pathogens. This idea follows from the notion that natural selection removes pathogen strains that are so “hot” that they kill their hosts and, therefore, themselves. Vaccines that let the hosts survive but do not prevent the spread of the pathogen relax this selection, allowing the evolution of hotter pathogens to occur. This type of vaccine is often called a leaky vaccine. When vaccines prevent transmission, as is the case for nearly all vaccines used in humans, this type of evolution towards increased virulence is blocked. But when vaccines leak, allowing at least some pathogen transmission, they could create the ecological conditions that would allow hot strains to emerge and persist. This theory proved highly controversial when it was first proposed over a decade ago, but here we report experiments with Marek’s disease virus in poultry that show that modern commercial leaky vaccines can have precisely this effect: they allow the onward transmission of strains otherwise too lethal to persist. Thus, the use of leaky vaccines can facilitate the evolution of pathogen strains that put unvaccinated hosts at greater risk of severe disease. The future challenge is to identify whether there are other types of vaccines used in animals and humans that might also generate these evolutionary risks.


Association of American Physicians and Surgeons Statement against Federal Vaccine Mandates

Association of American Physicians and Surgeons

"Vaccines are neither 100% safe nor 100% effective. Nor are they the only available means to control the spread of disease."
"The last measles death in the U.S. occurred in 2015"

To: Oversight and Investigations Subcommittee, House Energy and Commerce Committee

Senate Committee on Health, Education, Labor and Pensions

Re: Statement federal vaccine mandates

Feb. 26, 2019

Jane M. Orient, M.D., Executive Director
Association of American Physicians and Surgeons

"... Vaccines are necessarily risky, as recognized by the U.S. Supreme Court and by Congress. The Vaccine Injury Compensation Program has paid some $4 billion in damages, and high hurdles must be surmounted to collect compensation. The damage may be so devastating that most people would prefer restored function to a multimillion-dollar damage award.

The smallpox vaccine is so dangerous that you can’t get it now, despite the weaponization of smallpox. Rabies vaccine is given only after a suspected exposure or to high-risk persons such as veterinarians. The whole-cell pertussis vaccine was withdrawn from the U.S. market, a decade later than from the Japanese market, because of reports of severe permanent brain damage. The acellular vaccine that replaced it is evidently safer, though somewhat less effective.

The risk: benefit ratio varies with the frequency and severity of disease, vaccine safety, and individual patient factors. These must be evaluated by patient and physician, not imposed by a government agency..."


Paradoxically some vaccines make viruses worse

Vaccines save millions of lives every year by teaching our immune systems how to combat certain viruses or bacteria. But a new study suggests that, paradoxically, they could sometimes teach pathogens to become more dangerous as well.

The article cites Read's 2015 paper.




1999 Valsamakis: Altered Virulence of Vaccine Strains of Measles Virus after Prolonged Replication in Human Tissue
https://jvi.asm.org/content/73/10/8791


2005 Simonsen: Risk of death from flu increases proportionally with frequency of flu shots.
https://archinte.jamanetwork.com/article.aspx?articleid=486407


2008 CBS: The "neutral third party" boards that make vaccine guidelines are funded by vaccine producers.
http://www.youtube.com/watch?v=rfkYaetrJak


2008 Filippi: Viral Trigger for Type 1 Diabetes. This includes vaccine derived strains.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570378/


2015 CNBC: Public Health Officials Know: Recently Vaccinated Individuals Spread Disease
https://web.archive.org/web/20150715222107/http://www.cnbc.com/2015/03/03/globe-newswire-public-health-officials-know-recently-vaccinated-individuals-spread-disease.html


2015 Moro: Inactivated influenza vaccine given alone was most commonly associated with death reports in adults (51.4%).
https://academic.oup.com/cid/article/61/6/980/451431


2015 Read: Immunization selects for the most pathogenic forms of a virus.
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002198


2018 AAPS: Association of American Physicians and Surgeons Statement against Federal Vaccine Mandates
https://aapsonline.org/measles-outbreak-and-federal-vaccine-mandates/


ScienceMag: Paradoxically some vaccines make viruses worse
http://news.sciencemag.org/biology/2015/07/could-some-vaccines-make-diseases-more-deadly