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Vaccine derived measles virus causes fatal meningitis from an MMR shot.
Measles Inclusion-Body Encephalitis Caused by the Vaccine Strain of Measles Virus
We report a case of measles inclusion-body encephalitis (MIBE) occurring in an apparently healthy 21-month-old boy 8.5 months
after measles-mumps-rubella vaccination. He had no prior evidence of immune deficiency and no history of measles exposure or clinical disease. During hospitalization, a primary immunodeficiency characterized by a profoundly depressed CD8 cell count and dysgammaglobulinemia was demonstrated. A brain biopsy revealed histopathologic features consistent with MIBE, and measles antigens were detected by immunohistochemical staining. Electron microscopy revealed inclusions characteristic of paramyxovirus nucleocapsids within neurons, oligodendroglia, and astrocytes. The presence of measles virus in the brain tissue was confirmed by reverse transcription polymerase chain reaction. The nucleotide sequence in the nucleoprotein and fusion gene regions was identical to that of the Moraten and Schwarz vaccine strains; the fusion gene differed from known genotype A wild-type viruses.
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Vaccine strain measles in a healthy child 14 months-old.
"We demonstrated excretion of the Schwarz measles vaccine virus in a child with a vaccine-associated febrile rash illness in urine and in pharyngeal excretions."
"Virus excretion in vaccinees has been reported before [8-10], but to our knowledge, this is documented for the first time for the Schwarz vaccine strain. Interestingly, although the blood for serology testing was obtained 14 and 32 days after vaccination, the child still had no antibodies to rubella virus in either serum sample. It is unclear why there was no seroconversion to rubella 32 days after vaccination, although this is not an unusual finding."
"Competing interests:
Maja Santak is an employee of the Institute of Immunology, Zagreb, the national vaccine producer."
[8] Morfin F, Beguin A, Lina B, Thouvenot D. Detection of measles vaccine in the throat of a vaccinated child. Vaccine. 2002;20(11-12):1541-3.
[9] Rota PA, Khan AS, Durigon E, Yuran T, Villamarzo YS, Bellini WJ.. Detection of measles virus RNA in urine specimens from vaccine recipients. J Clin Microbiol. 1995;33(9):2485-8.
[10] Strebel PM, Papania MJ, Dayan GH, Halsey NA. Measles vaccine. In: Plotkin S, Orenstein W, Offit P, editors. Vaccines. 5th ed. Philadelphia: Elsevier; 2009.
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13 out of the 16 immunized measles cases had measles from the vaccine itself
To identify wild measles virus and vaccine virus by detection nucleic acid of clinical samples from measles patients with immunization history circulating in Beijing through multiplex real-time fluorescent PCR technology.
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How to tell wild vs. vaccine strain infections from measles
"Rashes are expected to occur after immunization; nucleic acid testing can be used when it is difficult to differentiate between wild and attenuated strains."
Translation: vaccines spread disease. Live virus vaccines reproduce in the gut and are excreted. This can infect others. Consider what an irony it is when a kid, vaccinated for measles, gets measles and the virus turns out to be from a vaccine in the first place. Not only did the shot not work preventing the illness, but it actuallt caused more disease: a classic case of the cure being worse than the disease.
"First, do no harm." - Hippocrates
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A five-year-old Canadian-born boy gets measles from the vaccine in 2013
"Although no microbiologically confirmed secondary cases of vaccine-associated measles have been previously described, we sent notification letters to advise all contacts of measles symptoms since the likelihood of transmission from an immunocompromised patient was low, but theoretically possible. We decided to stratify contacts into immune competent and compromised and to deal with the latter group conservatively by excluding them as if they were exposed to wild-type measles because the risk of transmission of disease in this population, while presumably very low, is unknown. However, no contacts self-identified as immunocompromised and there were no secondary cases. Subsequent genotyping confirmed that this case was caused by vaccine strain measles virus."
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Case of vaccine-associated measles in a two-year-old patient from British Columbia, Canada in 2013
In this report we describe a case of measles-mumps-rubella (MMR) vaccine-associated measles illness that was positive by both PCR and IgM, five weeks after administration of the MMR vaccine. Based on our literature review, we believe this is the first such case report which has implications for both public health follow-up of measles cases and vaccine safety surveillance.
We describe a case of vaccine-associated measles in a two-year-old patient from British Columbia, Canada, in October 2013, who received her first dose of measles-containing vaccine 37 days prior to onset of prodromal symptoms. Identification of this delayed vaccine-associated case occurred in the context of an outbreak investigation of a measles cluster.
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Fatal varicella in a 15-mo-old girl due to the vaccine-strain varicella-zoster virus
We describe a death in a 15-mo-old girl who developed a varicella-like rash 20 d after varicella vaccination that lasted for 2 mo despite acyclovir treatment. The rash was confirmed to be due to vaccine-strain varicella-zoster virus (VZV). This is the first case of fatal varicella due to vaccine-strain VZV reported from the United States. The patient developed severe respiratory complications that worsened with each new crop of varicella lesions; vaccine-strain VZV was detected in the bronchial lavage specimen. Sepsis and multi-organ failure led to death.
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Of the 194 measles virus sequences obtained in the United States in 2015, 73 were identified as vaccine derived
o During measles outbreaks, it is important to be able to rapidly distinguish between measles cases and vaccine reactions to avoid unnecessary outbreak response measures such as case isolation and contact investigations.
o Endemic transmission of measles virus (MeV) was interrupted in the Americas in 2002
o approximately 5% of recipients of measles virus-containing vaccine experience rash and fever which may be indistinguishable from measles
o During the measles outbreak in California in 2015, a large number of suspected cases occurred in recent vaccinees caused by he vaccine - 38%
o Of the 194 measles virus sequences obtained in the United States in 2015, 73 were identified as vaccine sequences (R. J. McNall, unpublished data). In contrast, only 11 of 542 cases genotyped in the National Reference Center for Measles, Mumps, and Rubella in Germany were associated with the vaccine virus.
o Genotyping is used to confirm the origin of an outbreak and to exclude endemic circulation, but it is also the only way to distinguish vaccine strains from wild-type viruses.
The WHO currently recognizes 24 genotypes of measles virus, and all of the vaccine strains are in a single genotype, genotype A. Wild-type viruses of genotype A are no longer circulating
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